Mitochondrial + redox research
FOXO4-DRI
Lyophilized mitochondrial and cellular-signaling research material
FOXO4-DRI is a senescence-pathway research peptide studied around FOXO4 and p53 interaction models.
Support can confirm any currently available COAs or batch documentation for this product.
Request available documentsConfirm an optional email signup to receive a single-use 10% welcome code.
Get catalog updatesFor laboratory research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure, mitigate, or prevent disease.
Mantener sellado, frío, seco y protegido de los cambios de calor. Confirme el almacenamiento específico del producto a su llegada.
Empaquetado para estabilidad en tránsito con soporte de pedidos disponible para rutas en climas cálidos.
Batch-linked certificate support is available through the documentation desk.
Contexto de investigación
Perfil de investigación de FOXO4-DRI
FOXO4-DRI is a cell-penetrating D-retro-inverso peptide developed for research into the interaction between FOXO4 and p53 in senescent cells. Preclinical studies examine whether disrupting that interaction changes p53 localization, apoptosis, senescence markers, tissue function, and age-associated phenotypes in cell and animal models. Its design and evidence base are distinct from broad antioxidant or mitochondrial compounds. FOXO4-DRI is selected for mechanism-specific senescence experiments where cell identity, peptide uptake, controls, and toxicity measurements are carefully defined. The published work remains preclinical; there is no established human clinical evidence, and senolytic findings should not be generalized beyond the original models.
Mecanismo propuesto
A D-retro-inverso cell-penetrating peptide designed to disrupt the FOXO4-p53 interaction in senescent cells. The proposed result is release and nuclear exclusion of p53 followed by preferential apoptosis of cells dependent on FOXO4-mediated survival signaling.
Efectos reportados en estudios
- Cell studies report p53 relocalization and apoptosis in selected senescent-cell models after FOXO4-DRI exposure.
- Aged-mouse studies reported reductions in senescence markers and improvements in selected fitness, fur-density, and renal-function measures.
- Selectivity across senescent cell types, off-target toxicity, delivery, and long-term consequences remain unresolved.
Criterios de investigación comunes
FOXO4-p53 binding, p53 localization, apoptosis, senescence-associated beta-galactosidase, p16 and p21, SASP factors, cell viability, tissue function, and off-target toxicity.
Evidencia y limitaciones
Evidence is limited to mechanistic cell and animal research. No established human clinical efficacy or safety data exist.
External reading
Literature for context—not product proof.
Third-party sources describe their own research materials and methods. They do not validate a specific Azure catalog batch.
Support and documentation
Questions about this product?
What documentation can I request before ordering?
Before ordering, contact support with the product name, selected format, andu2014if availableu2014an order or batch reference to request available batch-linked documentation.
What should I confirm before ordering?
Compare the product name, listed amount, physical form, storage note, price, and documentation route. When the order arrives, match the product and lot or batch reference to the order record and available documentation.